Why the study?
Patients with repaired COA may have aortic vasculopathy causing LV pressure overload, leading to hypothesized higher LV diastolic dysfunction even without hemodynamically significant COA.
Does repaired coarctation of aorta without significant re-coarctation increase the prevalence of left ventricular diastolic dysfunction compared to matched controls?
Population
Adult patients with mild COA (Doppler peak velocity < 2.5 m/s) and matched controls
Comparison
Adults with repaired mild COA vs controls without structural heart disease
Design
Propensity score-matched study
Key result
Adults with repaired, mild coarctation of the aorta had significantly worse left ventricular diastolic function, including a higher lateral E/e' ratio (10 vs 7, p<0.001), compared to matched controls.
Authors
Loading...
Supports closer LV diastolic surveillance post-repair; leaves open impact on outcomes and management.
Observational (n=408)
No
Does repaired coarctation of aorta without significant re-coarctation increase the prevalence of left ventricular diastolic dysfunction compared to matched controls?
Effect estimate: Mean difference 3 (95% CI 2-4)
Absolute Event Rate: 10% vs 7%
p-value: p=<0.001
Adults with repaired coarctation of the aorta have a significantly higher prevalence of LV diastolic dysfunction and LV hypertrophy compared to matched controls, suggesting ongoing LV pressure overload even without hemodynamically significant re-coarctation.
Egbe et al. (2020) conducted an observational in Repaired coarctation of aorta (n=408). Repaired coarctation of aorta vs. Propensity-matched controls without structural heart disease was evaluated on Lateral E/e' ratio (Mean difference 3, 95% CI 2-4, p=<0.001). Adults with repaired, mild coarctation of the aorta had significantly worse left ventricular diastolic function, including a higher lateral E/e' ratio (10 vs 7, p<0.001), compared to matched controls.