Adults with repaired, mild coarctation of the aorta had significantly worse left ventricular diastolic function, including a higher lateral E/e' ratio (10 vs 7, p<0.001), compared to matched controls.
Observational (n=408)
No
Does repaired coarctation of aorta without significant re-coarctation increase the prevalence of left ventricular diastolic dysfunction compared to matched controls?
Adults with repaired coarctation of the aorta have a significantly higher prevalence of LV diastolic dysfunction and LV hypertrophy compared to matched controls, suggesting ongoing LV pressure overload even without hemodynamically significant re-coarctation.
Effect estimate: Mean difference 3 (95% CI 2-4)
Absolute Event Rate: 10% vs 7%
p-value: p=<0.001
BACKGROUND: Left ventricular (LV) pressure overload and coronary artery disease are common in patients with coarctation of aorta (COA), and they are risk factors for LV diastolic dysfunction. Patients with COA may have aortic vasculopathy that can result in LV pressure overload even in the absence of hemodynamically significant COA. We therefore hypothesized that patients with mild COA (without hemodynamically significant COA) will have more LV diastolic dysfunction compared to controls. METHODS: Adult patients with mild COA (Doppler peak velocity 2 standard deviations above age-specific normative values) between adults with repaired COA and controls. RESULTS: , standard error = 1.25, p < 0.001). CONCLUSION: LV diastolic dysfunction was common in patients with COA, and the association with LVMI suggests that patients with COA may have ongoing LV pressure overload in the absence of hemodynamically significant re-coarctation.
Egbe et al. (Mon,) conducted a observational in Repaired coarctation of aorta (n=408). Repaired coarctation of aorta vs. Propensity-matched controls without structural heart disease was evaluated on Lateral E/e' ratio (Mean difference 3, 95% CI 2-4, p=<0.001). Adults with repaired, mild coarctation of the aorta had significantly worse left ventricular diastolic function, including a higher lateral E/e' ratio (10 vs 7, p<0.001), compared to matched controls.