Matthew J. Reed replied to a Key Question
Key Question · ASPIRED · ESC Congress 2026
Should the mortality difference change practice despite a neutral primary endpoint?
Immediate Ambulatory Electrocardiographic Monitoring in Syncope
New England Journal of MedicineMatthew J. Reed et al.
Matthew J. Reed
Cross-Cutting Cardiology · NHS Lothian
The mortality difference is an important and potentially practice-changing finding, but it needs to be interpreted cautiously in the context of a neutral primary endpoint. The trial was not powered to detect a difference in mortality, and mortality was not the primary outcome. The observed difference is therefore a secondary finding and should not, in isolation, be taken as definitive evidence that early monitoring reduces mortality.
