
Cardiology
Peer-reviewed research on semaglutide across obesity, type 2 diabetes, and cardiovascular outcome trials.
Synthesized from 8 evidence-backed clinical questions linked to this topic — 2 supporting the intervention, 1 against the intervention.
Does semaglutide vs placebo improve outcomes in Diabetes Mellitus, Non-Insulin-Dependent?
Low Certainty+ Favors benefitsemaglutide vs placebo
8 studies (14,315,258 patients) provide low-certainty evidence for benefit of semaglutide for the outcome in Diabetes Mellitus, Non-Insulin-Dependent.
Does semaglutide vs placebo improve outcomes in spine surgery?
Low Certainty+ Favors benefitsemaglutide vs placebo
12 studies (40,424 patients) provide low-certainty evidence for benefit of semaglutide for the outcome in spine surgery.
No claims extracted for this topic
Current and Emerging Roles of GLP1 Receptor Agonists Across the Spectrum of Left Ventricular Ejection Fraction in Heart Failure
Biomolecules — Crispino S — Nov 2025
Incretin-Based Therapies in Doxorubicin-Induced Cardiotoxicity: A Systematic Review of GLP-1 and Dual GIP/GLP-1 Agonists
Cardiovascular Toxicology — Khatami S — Jul 2026
Tirzepatide and reduced risk of pulmonary embolism and deep vein thrombosis: a multicenter U.S. cohort study
Frontiers in Endocrinology — Kahkedjian F — Jul 2026
Long-term effects of weight-reducing drugs in people with hypertension
Cochrane Database of Systematic Reviews — Spary-Kainz U — Jun 2026
Highlighting the latest research: May 2026
British Journal of Cardiac Nursing — McSharry S — May 2026
B52-20 A Broken Heart: Ozempic-Induced Takotsubo Cardiomyopathy
American Journal of Respiratory and Critical Care Medicine — Shah S — May 2026
Comparative 12-month cardiometabolic impact of semaglutide vs tirzepatide: a synthetic propensity-matched analysis
Cardiovascular Research — Fazio G — May 2026
Comparative real-world outcomes of tirzepatide vs semaglutide in patients with obesity and type2 diabetes: A retrospective propensity-matched cohort study
Diabetes and Vascular Disease Research — Qadeer A — May 2026
Metabolic and nutritional stress-associated dilated cardiomyopathy in the setting of semaglutide use and long-term nicotine replacement therapy: a case report and literature review
Therapeutic Advances in Drug Safety — Sriram S — May 2026
Reversion to normoglycemia with tirzepatide vs semaglutide in participants with obesity and prediabetes: a post hoc analysis of SURMOUNT-5
Journal of Endocrinological Investigation — Galindo R — Apr 2026
Hemodynamic Changes in Response to GLP-1 Treatment in ICD and CRT Patients: Insights From HeartLogic Sensor Data
European Journal of Heart Failure — Fussing F — Apr 2026
Semaglutide Effects on Insulin Sensitivity and β-Cell Function in Patients With Schizophrenia, Prediabetes, and Obesity Treated With Second-Generation Antipsychotics: Findings From the HISTORI Trial, a 30-Week Randomized, Placebo-Controlled Trial With Semaglutide 1.0 mg Weekly
Diabetes Care — Ganeshalingam A — Mar 2026
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Semaglutide (also known as Semaglutide, Ozempic, Wegovy). Peer-reviewed research on semaglutide across obesity, type 2 diabetes, and cardiovascular outcome trials.
As of 2026-08-14, the scientific consensus on Semaglutide is unknown. No claims extracted for this topic
This evidence brief synthesizes Synapse's enriched cardiology corpus; cite as synapsesocial.com/topics/peptide-semaglutide.
Deterministic synthesis from Synapse's enriched corpus — 47 words. No AI-generated novel content; every figure is sourced from the underlying paper, guideline, or trial record linked on this page.
Explore every Semaglutide paper on Synapse with AI-enriched clinical evidence, PICO analysis, and methodology classification.
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