Overview
Unverified · drafted by AI from the sources cited below
Definition
Coronary occlusion is defined as a complete blockage of blood flow through one of the coronary arteries, which is usually from coronary atherosclerosis.1 Percutaneous coronary intervention is a family of percutaneous techniques that are used to manage coronary occlusion.2
Treatment
Percutaneous coronary intervention encompasses techniques used to manage coronary occlusion, including standard balloon angioplasty, the placement of intracoronary stents, and atheroablative technologies.1 Intravascular imaging-guided percutaneous coronary intervention with intravascular ultrasound or optical coherence tomography showed superior clinical outcomes compared with angiography-guided percutaneous coronary intervention.2 Additionally, in a trial of 1500 patients with three-vessel coronary artery disease, fractional flow reserve-guided percutaneous coronary intervention was compared with coronary-artery bypass grafting.3
New research on Chronic total occlusion PCI
TCT-24 Integrated Clinical, Genetic, Retinal, and Facial Imaging Model for Non-invasive Detection of Coronary Artery Disease
JACC — Lin L — Nov 2026
Journal clubs discussing Chronic total occlusion PCI
Recent sessions
CCU #bruinhearts Journal Club OPTIMAL
UCLA #bruinhearts — Tue, Sep 22, 3:00 PM EDT — 1 attended
ORBITA-CTO: The Heart of the Matter
OPCI Journal Club — Fri, Jun 26, 5:49 PM EDT — 15 attended
Sessions from public communities on Synapse. RSVP to join the live discussion.
Key papers
Angiographic quantitative flow ratio-guided coronary intervention (FAVOR III China): a multicentre, randomised, sham-controlled trial
The Lancet
443 citations · 2021 · among the most cited on Chronic total occlusion PCI
Fractional Flow Reserve–Guided PCI as Compared with Coronary Bypass Surgery
New England Journal of Medicine — Fearon W
375 citations · 2021 · among the most cited on Chronic total occlusion PCI
Optical Coherence Tomography–Guided or Intravascular Ultrasound–Guided Percutaneous Coronary Intervention: The OCTIVUS Randomized Clinical Trial
Circulation — Kang D
176 citations · 2023 · among the most cited on Chronic total occlusion PCI
Intravascular ultrasound-guided versus angiography-guided percutaneous coronary intervention in acute coronary syndromes (IVUS-ACS): a two-stage, multicentre, randomised trial
The Lancet — Ge Z
167 citations · 2024 · among the most cited on Chronic total occlusion PCI
How this page is built
A clinical question appears here only when its condition matches this topic, an outcome and a comparator were extracted from the studies, at least two studies and a patient count are on file, and the certainty is low or higher.
Supports benefit, no benefit shown, and mixed describe the direction of the measured effect. No benefit shown means the evidence does not support a benefit. It is not a finding of harm. Too little evidence means the question did not clear that bar.
Study count, RCT count, and patient count are separate. The patient total adds only studies that are linked into a study family and whose sample size is not flagged as implausible. A reversal is listed only when at least one randomized trial sits on each side of the change.
The overview is drafted from the guideline recommendations, trials, papers, and questions on this page, and every sentence has to cite one of them. It stays unverified until an NPI-verified clinician or a Synapse admin approves it. Approving records that person's name.
