Interventional Cardiology
Chronic total occlusion PCI
CTO intervention techniques and outcomes
Emerging pathwayAlso known as: CTO PCI, chronic total occlusion, CTO intervention
384
Clinical questions
91
Evidence-backed
33
Claims analyzed
Interventional Cardiology
CTO intervention techniques and outcomes
Synthesized from 91 evidence-backed clinical questions linked to this topic — 15 supporting the intervention, 12 against the intervention, 2 still contested.
Does clopidogrel vs placebo improve outcomes in Acute Coronary Syndrome?
Low Certainty+ Favors benefitclopidogrel vs placebo · Cardiac Output
51 studies (18,758,133 patients) provide low-certainty evidence for benefit of clopidogrel for Cardiac Output in Acute Coronary Syndrome.
Does aspirin vs placebo improve outcomes in Myocardial Infarction?
Low Certainty+ Favors benefitaspirin vs placebo
20 studies (1,016,203 patients) provide low-certainty evidence for benefit of aspirin for the outcome in Myocardial Infarction.
Does antiplatelet vs placebo improve All-Cause Mortality in Percutaneous Coronary Intervention?
Low Certainty+ Favors benefitantiplatelet vs placebo · All-Cause Mortality
4 studies (140,763 patients) provide low-certainty evidence for benefit of antiplatelet for All-Cause Mortality in Percutaneous Coronary Intervention.
Does ticagrelor vs clopidogrel improve outcomes in Percutaneous Coronary Intervention?
Low Certainty− Favors harmticagrelor vs clopidogrel
4 studies (106,292 patients) provide low-certainty evidence against benefit of ticagrelor for the outcome in Percutaneous Coronary Intervention.
Does aspirin vs p2y12 inhibitor improve outcomes in Percutaneous Coronary Intervention?
Low Certainty+ Favors benefitaspirin vs p2y12 inhibitor
4 studies (73,264 patients) provide low-certainty evidence for benefit of aspirin for the outcome in Percutaneous Coronary Intervention.
Does prasugrel vs clopidogrel improve outcomes in Percutaneous Coronary Intervention?
Low Certainty+ Favors benefitprasugrel vs clopidogrel
5 studies (67,531 patients) provide low-certainty evidence for benefit of prasugrel for the outcome in Percutaneous Coronary Intervention.
Does direct oral anticoagulant vs vitamin k antagonist improve outcomes in Atrial Fibrillation?
Insufficient~ Mixed resultsdirect oral anticoagulant vs vitamin k antagonist
9 studies (29,403 patients) provide insufficient evidence with mixed findings regarding direct oral anticoagulant for the outcome in Atrial Fibrillation.
Does protamines vs placebo improve outcomes in RNAx report bleeding complications?
Insufficient~ Mixed resultsprotamines vs placebo
2 studies (7,196 patients) provide insufficient evidence with mixed findings regarding protamines for the outcome in RNAx report bleeding complications.
Emerging evidence with 33 primary claims
Specific, answerable questions in this area — each with its own synthesized evidence and consensus. Open one to see the forest plot, source trials, and how the consensus has changed over time.
Does clopidogrel vs placebo improve outcomes in Acute Coronary Syndrome?
Low Certainty+ Favors benefitclopidogrel vs placebo · Cardiac Output
Does antiplatelet vs placebo improve All-Cause Mortality in Percutaneous Coronary Intervention?
Low Certainty+ Favors benefitantiplatelet vs placebo · All-Cause Mortality
1 question with new evidence. Nothing practice-threatening. 5 new results triaged.
Follow this topic to get this summary as a weekly digest.
Questions where the synthesized consensus has shifted as new trials were indexed.
ORBITA-CTO: The Heart of the Matter
OPCI Journal Club — Fri, Jun 26, 5:49 PM EDT — 15 attended
This Week's Session
U Miami Journal Club — Wed, May 20, 3:00 PM EDT
Sessions from public journal clubs on Synapse. RSVP to join the live discussion.
Compared Outcomes of ST-Segment–Elevation Myocardial Infarction Patients With Multivessel Disease Treated With Primary Percutaneous Coronary Intervention and Preserved Fractional Flow Reserve of Nonculprit Lesions Treated Conservatively and of Those With Low Fractional Flow Reserve Managed Invasively: Insights From the FLOWER-MI Trial
Circulation Cardiovascular Interventions — Denormandie P — Aug 2021
FFR-Negative Nonculprit High-Risk Plaques and Clinical Outcomes in High-Risk Populations: An Individual Patient-Data Pooled Analysis From COMBINE (OCT-FFR) and PECTUS-obs
Circulation Cardiovascular Interventions — Volleberg R — Jan 2025
Long-Term Prognostic Implications of Non-Culprit Lesions in Patients Presenting With an Acute Myocardial Infarction: Is It the Angiographic Stenosis Severity or the Underlying High-Risk Morphology?
Circulation — Dai J — Jan 2025
Incidence and Predictors of Radial Artery Occlusion Associated Transradial Catheterization
International Journal of Medical Sciences — Tunçez A — Jan 2013
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Chronic total occlusion PCI (also known as CTO PCI, chronic total occlusion, CTO intervention). CTO intervention techniques and outcomes
Synapse tracks 6 specific clinical questions in Chronic total occlusion PCI, each synthesized independently from its own trial evidence. They include: "Does clopidogrel vs placebo improve outcomes in Acute Coronary Syndrome?"; "Does antiplatelet vs placebo improve All-Cause Mortality in Percutaneous Coronary Intervention?"; "Does antiplatelet therapy vs placebo improve Major Bleeding in At high risk for bleeding?"; "Does sirolimus vs sirolimus improve Cardiovascular Mortality in Percutaneous Coronary Intervention?"; "Does aspirin vs clopidogrel improve outcomes in Diabetes Mellitus?".
As of 2026-08-14, the scientific consensus on Chronic total occlusion PCI is emerging. Emerging evidence with 33 primary claims Based on 33 analyzed claims across Synapse's enriched corpus, the evidence shows.
This evidence brief synthesizes Synapse's enriched cardiology corpus; cite as synapsesocial.com/topics/chronic-total-occlusion-pci.
Deterministic synthesis from Synapse's enriched corpus — 137 words. No AI-generated novel content; every figure is sourced from the underlying paper, guideline, or trial record linked on this page.
Explore every Chronic total occlusion PCI paper on Synapse with AI-enriched clinical evidence, PICO analysis, and methodology classification.
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Procedural and 1-year outcomes following large vessel coronary artery perforation treated by covered stents implantation: Multicentre CRACK registry
PLoS ONE — Wańha W — May 2021