Peter Libby

Matthias Nahrendorf

Cardiac Imaging · Boston University

9d

“

The ancient fight-or-flight responses to injury stimulate immune cell activities that are involved in wound healing. But when the 'wound' is in the heart and caused by atherosclerosis, that increased activity actually accelerates the underlying disease. While most of this work was done in mice, we have hints that something similar may happen in human patients -- for example, we found increased numbers of blood stem cells in the spleens of patients who had died shortly after a heart attack.

Paul M Ridker

General / Preventive / Lipids · Brigham and Women's Hospital

2w

“

Although we believe this expanded indication for statin therapy to be a move in the right direction, it should be noted that this regulatory recommendation was not made on the basis of the trial's prespecified primary endpoint, did not take into account the enrolment criterion in JUPITER that required all participants to have an hsCRP of 2 mg/L or greater, which augmented absolute risk, and does not address most of the patients actually studied.

Paul Ridker

General / Preventive / Lipids · Brigham and Women's Hospital

3w

“

When we designed the main trial, we knew we were going after atherosclerosis and we knew we were going after cancer.

Farouc Jaffer

Interventional Cardiology · Boston University

3w

“

We need to do a better job of phenotyping the artery beyond structure, plaque burden, and fibrous cap thickness.

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The categories of patients we describe emerged from our clinical observations and increasing understanding of the biological underpinnings and cardiovascular implications of CHIP. The classification is helpful to inform personalized management of this heterogeneous population.

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Overall, these animal data suggest RBF in acute, proximal DVT, whether achieved by mechanical or pharmacomechanical means, is more likely to occur if the intervention occurs early, and early RBF by any means reduces long-term molecular and cellular consequences of DVT. In ATTRACT, subjects randomized early after symptom onset did not benefit from PCDT, and this may indicate that therapeutic anticoagulation alone is effective for fresh thrombus, highlighting the importance of rapidly achieved anticoagulation. In contrast, late intervention may occur beyond a reversible period of DVT sequelae.

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