Key result
Early reperfusion and targeted medical therapies mitigate adverse cardiovascular remodelling in CAD and heart failure.
Why the study?
Remodelling of myocardium and vasculature in coronary artery disease and heart failure involves complex cellular and structural changes that are not fully understood and have therapeutic implications.
Understanding the complex cellular and molecular pathways of cardiovascular remodeling provides a strong physiological foundation for developing and refining therapies to prevent heart failure progression.
Remodelling is a response of the myocardium and vasculature to a range of potentially noxious haemodynamic, metabolic, and inflammatory stimuli. Remodelling is initially functional, compensatory, and adaptive but, when sustained, progresses to structural changes that become self-perpetuating and pathogenic. Remodelling involves responses not only of the cardiomyocytes, endothelium, and vascular smooth muscle cells, but also of interstitial cells and matrix. In this Review we characterise the remodelling processes in atherosclerosis, vascular and myocardial ischaemia-reperfusion injury, and heart failure, and we draw attention to potential avenues for innovative therapeutic approaches, including conditioning and metabolic strategies.
No takes yet. Share an insight, caveat, or question.
Heusch et al. (2014) conducted a review in Coronary artery disease and heart failure. Cardiovascular remodelling in coronary artery disease and heart failure involves progressive structural and functional alterations that can be mitigated by early reperfusion and targeted medical therapies.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: