Key result
Cardiac remodelling is a sequence of molecular, cellular, and interstitial events driven by oxidative stress and neurohormonal activation that leads to the progression of heart failure.
Design
Review
Authors
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Emphasizes oxidative stress and neurohormonal pathways as HF therapy targets; extends mechanistic models while leaving clinical translation open.
This review summarizes the molecular and cellular mechanisms of cardiac remodelling, highlighting the transition from adaptive hypertrophy to maladaptive heart failure driven by oxidative stress and neurohormonal activation.
Pontes et al. (2016) conducted a review in Cardiac remodelling and heart failure. Cardiac remodelling is a sequence of molecular, cellular, and interstitial events driven by oxidative stress and neurohormonal activation that leads to the progression of heart failure.
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