Overview
Unverified · drafted by AI from the sources cited below
Definition
Percutaneous coronary intervention encompasses a family of percutaneous techniques that are used to manage coronary occlusion.1 These interventions include standard balloon angioplasty, the placement of intracoronary stents, and atheroablative technologies.1 Prompt myocardial revascularization with percutaneous coronary intervention reduces infarct size and improves outcomes in patients with ST-segment elevation myocardial infarction.2
Diagnosis and risk stratification
Pressure wire-based physiological measurement identifies flow-limiting lesions more accurately than visual angiographic assessment.1 The quantitative flow ratio is an angiography-based approach to estimate the fractional flow reserve for lesion selection in patients with 50-90% diameter stenosis.1 Acute coronary occlusions, defined as 100% stenosis, can occur without traditional electrocardiographic criteria for ST-segment elevation myocardial infarction.2
Treatment
Drug-eluting stent technologies have improved procedural efficacy and safety, although in-stent restenosis still occurs at a rate of 1%-2% per year.1 For patients with ST-segment elevation myocardial infarction and multivessel disease, complete revascularization is recommended.2 Intraprocedural cardiac arrest is a severe complication occurring in 0.93% of interventions overall, including 0.24% of elective procedures, and it results in in-hospital death for 40.5% of these affected patients.3
New research on Percutaneous coronary intervention
Impact of inflammation in patients with controlled standard modifiable risk factors (SMuRFs) undergoing percutaneous coronary intervention
Heart — Oliva A — Oct 2026
Journal clubs discussing Percutaneous coronary intervention
Recent sessions
CCU #bruinhearts Journal Club OPTIMAL
UCLA #bruinhearts — Tue, Sep 22, 3:00 PM EDT — 1 attended
#bruinhearts CCU Journal Club: ISCHEMIA trial
UCLA #bruinhearts — Tue, Aug 25, 3:00 PM EDT — 3 attended
PRO-TAVI: The Heart of the Matter
OPCI Journal Club — Fri, Jul 24, 12:00 PM EDT
ORBITA-CTO: The Heart of the Matter
OPCI Journal Club — Fri, Jun 26, 5:49 PM EDT — 15 attended
Sessions from public communities on Synapse. RSVP to join the live discussion.
Key papers
Randomized Trial of Interleukin-6 Receptor Inhibition in Patients With Acute ST-Segment Elevation Myocardial Infarction
Journal of the American College of Cardiology — Broch K
449 citations · 2021 · among the most cited on Percutaneous coronary intervention
Angiographic quantitative flow ratio-guided coronary intervention (FAVOR III China): a multicentre, randomised, sham-controlled trial
The Lancet
429 citations · 2021 · among the most cited on Percutaneous coronary intervention
Coronary In-Stent Restenosis
Journal of the American College of Cardiology — Giustino G
417 citations · 2022 · among the most cited on Percutaneous coronary intervention
Fractional Flow Reserve–Guided PCI as Compared with Coronary Bypass Surgery
New England Journal of Medicine — Fearon W
360 citations · 2021 · among the most cited on Percutaneous coronary intervention
How this page is built
A clinical question appears here only when its condition matches this topic, an outcome and a comparator were extracted from the studies, at least two studies and a patient count are on file, and the certainty is low or higher.
Supports benefit, no benefit shown, and mixed describe the direction of the measured effect. No benefit shown means the evidence does not support a benefit. It is not a finding of harm. Too little evidence means the question did not clear that bar.
Study count, RCT count, and patient count are separate. The patient total adds only studies that are linked into a study family and whose sample size is not flagged as implausible. A reversal is listed only when at least one randomized trial sits on each side of the change.
The overview is drafted from the guideline recommendations, trials, papers, and questions on this page, and every sentence has to cite one of them. It stays unverified until an NPI-verified clinician or a Synapse admin approves it. Approving records that person's name.
