It is currently unclear how exercise may modulate tumor behavior within the tumor microenvironment .

Breast cancer

Breast cancer systemic therapy: HER2-directed antibody-drug conjugates, CDK4/6 inhibitors, oral SERDs, PI3K/AKT inhibitors and FDA approvals.

Also called breast neoplasms, HER2-positive breast cancer, HR-positive breast cancer, metastatic breast cancer

Sources: 12 new papers · 5 key papers · updated Oct 20, 2026

Overview

Unverified · drafted by AI from the sources cited below

Definition

Breast cancer refers to tumors or cancer of the human breast.1

Diagnosis and risk stratification

Women diagnosed with hormone-receptor-positive breast cancer remain at a constant annual risk of recurrence for at least 20 years after diagnosis.1 Between 2002-2016, a cohort study of 11,486 Black females found that 531 developed a breast or gynecological cancer.2 Delays in breast cancer presentation and diagnosis can occur in young women aged 40 years or younger, with factors such as lower annual income associated with presentation delay.3 Additionally, sexual orientation and gender identity minorities experience disparities in recommended breast cancer screening, as seen in an analysis of 663,924 respondents.4 Extracellular signaling may also play a role in risk stratification, as human estrogen-receptor-positive breast tumors exhibit higher mast cell density and increased stem cell factor levels, which are associated with poorer overall survival.5

Treatment

Advances in adjuvant treatment have improved outcomes, and the large majority of women with operable cancer are expected to be alive and recurrence-free in 5 years.1 Adjuvant hormonal therapies, such as aromatase inhibitors in postmenopausal women, are sometimes extended beyond the typically prescribed 5 years.1 Regular exercise and physical activity are encouraged for the primary prevention and adjuvant treatment of breast cancer.2 During adjuvant chemotherapy, patients may experience symptom changes such as fatigue, pain, and appetite loss that correlate negatively with functional scales.3 Surgery remains the cornerstone of management, and regional anesthesia techniques like the erector spinae plane block can reduce postoperative morphine consumption with a mean difference of -5.77.4

New research on Breast cancer

Patterns of social determinants of health screening and health-related social needs among patients with newly diagnosed breast cancer in a safety-net system

Breast Cancer Research and Treatment — Su M — Oct 2026

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Associations of surgical breast cancer treatment at regional or community hospitals with patient-reported experience measures

Breast Cancer Research and Treatment — Gonzales S — Oct 2026

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LINC01537 Regulates Malignant Phenotypes and Predicts Prognosis in Breast Cancer, and Its Bioinformatics Analysis

Journal of Biochemical and Molecular Toxicology — Guo Y — Oct 2026

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Estradiol-associated extracellular signaling in the human breast in vivo identifies mast cells as tumor-supportive stromal mediators

OncoImmunology — Abrahamsson A — Oct 2026

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Current status of lymphedema-related health information-seeking behavior and its associated factors among postoperative breast cancer patients: a cross-sectional study

Supportive Care in Cancer — Zheng H — Oct 2026

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Analgesic efficacy of uni-level erector spinae plane block in breast cancer surgery patients: a systematic review and Meta-analysis

BMC Anesthesiology — El-Khalifa B — Oct 2026

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Delays in breast cancer presentation, diagnosis, and treatment in young women

Cancer — Zhang B — Oct 2026

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EORTC QLQ-C30 symptom components and their functional correlates during adjuvant chemotherapy for early breast cancer: a multivariate analysis. Data from GEICAM/2003-02 study

Quality of Life Research — Blasco A — Oct 2026

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Management, Upgrade Rates, and Radiologic Surveillance of Screen-Detected High-Risk Breast Lesions

Radiology Imaging Cancer — Veer E — Oct 2026

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Targeting SUV39H2 exon skipping reverses resistance to CDK4/6 inhibitors via transcriptional activation of p21

Science Advances — Yu S — Oct 2026

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ESR1 mutations are associated with enhanced MTORC1 signaling in a context-dependent manner

Communications Biology — Marchi T — Oct 2026

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Integrative methylome and transcriptome analyses identify LHX3 as an epigenetically downregulated marker with tumor suppressive properties in breast cancer

PLoS ONE — Farooq K — Oct 2026

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How this page is built

A clinical question appears here only when its condition matches this topic, an outcome and a comparator were extracted from the studies, at least two studies and a patient count are on file, and the certainty is low or higher.

Supports benefit, no benefit shown, and mixed describe the direction of the measured effect. No benefit shown means the evidence does not support a benefit. It is not a finding of harm. Too little evidence means the question did not clear that bar.

Study count, RCT count, and patient count are separate. The patient total adds only studies that are linked into a study family and whose sample size is not flagged as implausible. A reversal is listed only when at least one randomized trial sits on each side of the change.

The overview is drafted from the guideline recommendations, trials, papers, and questions on this page, and every sentence has to cite one of them. It stays unverified until an NPI-verified clinician or a Synapse admin approves it. Approving records that person's name.

Breast cancer

Overview

Definition

Diagnosis and risk stratification

Treatment

Open questions

New research on Breast cancer

Key papers

How this page is built

Leading authors