In a mouse model, in utero and neonatal sertraline exposure significantly lengthened the peak-to-peak time of calcium oscillation in neonatal cardiomyocytes from 784 ms to 1,121 ms.
Does perinatal sertraline exposure alter calcium handling and serotonin signaling in mouse cardiomyocytes?
Perinatal sertraline exposure disrupts calcium handling and serotonin signaling in neonatal mouse cardiomyocytes, leading to mild echocardiographic changes in adulthood.
Absolute Event Rate: 1121% vs 784%
p-value: p=<0.001
Sertraline exposure during development decreased the expression of critical genes in calcium regulation and lengthened periods in calcium oscillation in neonatal cardiomyocytes. Sertraline upregulated specific microRNAs that may modulate serotonin signaling in neonatal cardiac tissues, which corresponded with a decrease in the levels of the corresponding target mRNAs. Although the echocardiograms in our adult mice suggest a mild phenotype associated with sertraline exposure, these upregulated microRNAs (miRNAs) have been linked to adult cardiovascular disease and heart failure.
Lu et al. (Fri,) conducted a other in Sertraline exposure during development (n=343). Sertraline vs. Saline was evaluated on Peak-to-peak time of calcium oscillation in neonatal cardiomyocytes (ms) (p=<0.001). In a mouse model, in utero and neonatal sertraline exposure significantly lengthened the peak-to-peak time of calcium oscillation in neonatal cardiomyocytes from 784 ms to 1,121 ms.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: