Multimodal Algorithms for the Classification of Circulation States During Out-of-Hospital Cardiac Arrest

Goal: Identifying the circulation state during out-of-hospital cardiac arrest (OHCA) is essential to determine what life-saving therapies to apply. Currently algorithms discriminate circulation (pulsed rhythms, PR) from no circulation (pulseless electrical activity, PEA), but PEA can be classified into true (TPEA) and pseudo (PPEA) depending on cardiac contractility. This study introduces multi-class algorithms to automatically determine circulation states during OHCA using the signals available in defibrillators. Methods: A cohort of 60 OHCA cases were used to extract a dataset of 2506 5-s segments, labeled as PR (1463), PPEA (364) and TPEA (679) using the invasive blood pressure, experimentally recorded through a radial/femoral cannulation. A multimodal algorithm using features obtained from the electrocardiogram, the thoracic impedance and the capnogram was designed. A random forest model was trained to discriminate three (TPEA/PPEA/PR) and two (PEA/PR) circulation states. The models were evaluated using repeated patient-wise 5-fold cross-validation, with the unweighted mean of sensitivities (UMS) and F 1 -score as performance metrics. Results: The best model for 3-class had a median (interquartile range, IQR) UMS and F 1 of 69.0% (68.0-70.1) and 61.7% (61.0-62.5), respectively. The best two class classifier had median (IQR) UMS and F 1 of 83.9% (82.9-84.5) and 76.2% (75.0-76.9), outperforming all previous proposals in over 3-points in UMS. Conclusions: The first multiclass OHCA circulation state classifier was demonstrated. The method improved previous algorithms for binary pulse/no-pulse decisions. Significance: Automatic multiclass circulation state classification during OHCA could contribute to improve cardiac arrest therapy and improve survival rates.