Deep Learning-Based Optical Coherence Tomography and Optical Coherence Tomography Angiography Image Analysis: An Updated Summary

ABSTRACT: Deep learning (DL) is a subset of artificial intelligence based on deep neural networks. It has made remarkable breakthroughs in medical imaging, particularly for image classification and pattern recognition. In ophthalmology, there are rising interests in applying DL methods to analyze optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) images. Studies showed that OCT and OCTA image evaluation by DL algorithms achieved good performance for disease detection, prognosis prediction, and image quality control, suggesting that the incorporation of DL technology could potentially enhance the accuracy of disease evaluation and the efficiency of clinical workflow. However, substantial issues, such as small training sample size, data preprocessing standardization, model robustness, results explanation, and performance cross-validation, are yet to be tackled before deploying these DL models in real-time clinics. This review summarized recent studies on DL-based image analysis models for OCT and OCTA images and discussed the potential challenges of clinical deployment and future research directions.