A Mass Spectrometric Labeling Strategy for High-Throughput Reaction Evaluation and Optimization: Exploring C−H Activation

The functional groups and heterocyclic classes known to be compatible with a directed C−H activation with Ru3(CO)12 has been expanded through development of a new substrate screening strategy. Following C−H activation, a library of products is MS-labeled and rapidly evaluated by positive ion electrospray ionization mass spectrometry (see scheme) to directly identify successful products and their yields.