Female gender was not associated with a difference in long-term MACCE compared to male gender after revascularization for three-vessel disease (25.8% vs 27.5%; HR 0.99, 95% CI 0.88-1.17; p=0.820).
Cohort (n=3,776)
No
Does female gender impact the frequency of MACCE in patients with three-vessel disease undergoing revascularization?
In patients with three-vessel coronary disease undergoing revascularization, long-term outcomes do not differ significantly by gender.
Hazard Ratio: 0.99 (95% CI 0.88–1.17)
Absolute Event Rate: 25.8% vs 27.5%
p-value: p=0.820
Objective: To investigate the impact of gender on long-term outcomes after revascularization in patients with three-vessel disease (TVD), a severe and challenging subtype of coronary artery disease. Methods: This was a single center retrospective cohort study. A total of 3776 patients with TVD who underwent revascularization between 2013 and 2018 were analyzed and were divided into the female group (n = 1039, 27.5%) and the male group (n = 2737, 72.5%). We performed a 1:2 propensity score matching (PSM) to balance the baseline characteristics, and a total of 1506 (504 matched pairs) patients were created after undertaking PSM. The primary outcome was the frequency of major adverse cardiac and cerebrovascular events (MACCE) including all-cause death, myocardial infarction, repeat revascularization, stroke, and readmission for angina pectoris or heart failure. The secondary outcome was the incidence of all-cause death. Results: Through 2.4-year follow-up, no significant differences in MACCE (25.8% vs 27.5%, p = 0.279) and all-cause death (2.1% vs 2.2%, p = 0.888) were observed between the two cohorts. Similar results as with the early detection were obtained in propensity-matched patients. Multivariable analysis revealed that female gender (hazard ratio 0.99, 95% confidence interval 0.88-1.17, p = 0.820) was not an independent predictor of MACCE but percutaneous coronary intervention (compared with coronary artery bypass graft surgery), hypertension, diabetes mellitus, atrial fibrillation, left main trunk involvement and left ventricular ejection fraction ≤40% were independently associated with a higher MACCE rate in these patients. Conclusion: For patients with TVD after coronary revascularization, there were no gender-based differences in the long-term outcomes and female gender was not an independent predictor of MACCE.
Liu et al. (Fri,) conducted a cohort in Three-vessel coronary artery disease (n=3,776). Female gender vs. Male gender was evaluated on Major adverse cardiac and cerebrovascular events (MACCE) including all-cause death, myocardial infarction, repeat revascularization, stroke, and readmission for angina pectoris or heart failure (HR 0.99, 95% CI 0.88-1.17, p=0.820). Female gender was not associated with a difference in long-term MACCE compared to male gender after revascularization for three-vessel disease (25.8% vs 27.5%; HR 0.99, 95% CI 0.88-1.17; p=0.820).