A single bout of exercise significantly increased muscle and adipose tissue LPL activity in men, whereas LPL activity remained unchanged in women.
Does a single bout of exercise affect skeletal muscle and adipose tissue lipoprotein lipase activity differently in healthy lean men and women?
Acute exercise increases muscle and adipose tissue lipoprotein lipase activity in men but not women, indicating significant gender differences in the metabolic response to exercise.
p-value: p=0.023
OBJECTIVE: To determine whether gender differences exist in lipoprotein lipase (LPL) activity in response to exercise and/or insulin. Exercise and insulin are known modulators of LPL activity in men, but this is less clear in women. LPL activity may predict propensity for obesity; therefore, understanding its modulators is of considerable importance. RESEARCH METHODS AND PROCEDURES: Gender differences in skeletal muscle and adipose tissue LPL activity were determined after a single bout of exercise followed by a hyperinsulinemic/euglycemic clamp and compared with an identical rest day in healthy lean men (n = 10) and women (n = 10). Muscle and adipose tissue biopsies were obtained pre- (post-exercise vs. rest) and post-clamp. RESULTS: Basal levels of muscle and adipose tissue LPL activity were not different between men and women. There was, however, a significant gender by day interaction for muscle LPL activity (p = 0.023) and adipose tissue LPL activity (p = 0.013). In muscle, this was because of a significant increase in LPL activity on the exercise vs. rest day in men (p < 0.001) but not women. Adipose tissue LPL activity also increased significantly in men on the exercise day relative to rest day (p = 0.04) but decreased in women (p = 0.10). The hyperinulinemic/euglycemic clamp had no independent effect on tissue LPL activity, in either gender, after rest or exercise. DISCUSSION: In the 3 to 4 hours after exercise, muscle and adipose tissue LPL activity increased significantly in men, whereas LPL activity remained unchanged in women.
Perreault et al. (Sun,) conducted a other in Healthy (n=20). Single bout of exercise followed by a hyperinsulinemic/euglycemic clamp vs. Identical rest day was evaluated on Skeletal muscle and adipose tissue LPL activity (p=0.023). A single bout of exercise significantly increased muscle and adipose tissue LPL activity in men, whereas LPL activity remained unchanged in women.