Engineering matrix-embedded dual-drug eluting biodegradable surgical sutures for prophylaxis against surgical site infections

Key Points

• The aim is to develop biodegradable sutures that release antibiotics and anti-inflammatories to prevent infections after surgery.
• Engineered sutures using solvent-free hot-melt extrusion.
• Sutures deliver immediate and sustained release of levofloxacin and ibuprofen.
• Sutures demonstrated effective prevention of surgical site infections.
• Showed controlled release of levofloxacin and ibuprofen to manage inflammation.