Higher real circadian blood pressure variability in hypertensive men was associated with greater interventricular septum thickness (1.381 vs 1.270; P<0.00001) and other morpho-functional changes.
Observational (n=100)
Does higher circadian blood pressure variability correlate with adverse left and right ventricular morpho-functional changes in hypertensive and normotensive patients?
Higher circadian blood pressure variability is associated with adverse left and right ventricular remodeling in untreated hypertensive men.
Absolute Event Rate: 1.381% vs 1.27%
p-value: p=<0.00001
Objective: Aim of the study was to assess an influence of an average real circadian blood pressure variability (CBPV) on left and right ventricular morpho-functional parameters in patients with normal and high blood pressure. Design and method: A total of 75 untreated male hypertensive patients (mean age 57.13± 7.27 years) and 25 voluntary healthy male individuals (mean age 57.56±7.55 years) were included into the study. 24-hour Ambulatory blood pressure measurement (ABPM) was performed by the cuff-oscillometric method to evaluate the real CBPV. Heart ultrasonography was performed in every patient to reveal morpho-functional changes of left and right ventricles in patients with normo- and hypertension. Results: Maximal real CBPV in hypertensives was 1.285 vs 0.434 in normotensives, Minimal -2,571 vs -0.913 in normotensives, Median -0,762 vs -0.13 in normotensives and variation range was 3.856 in hypertensives vs 3.347 in normotensives. Patients with lower real CBPV (-0.762, n=41) had significantly lower interventricular septum thickness (1.270±0.134 vs 1.381±0.151; P-0.13, n=11) did not show any statistically significant difference in regards of all the parameters measured above. Conclusions: Hypertensive patients in comparison with normotensive individuals are prone to more expressed and higher real CBPV. In our study, higher real CBPV was related with well-marked left and right ventricular morpho-functional changes mainly in hypertensive patients.
Rekhviashvili et al. (Fri,) conducted a observational in Hypertension (n=100). Higher real circadian blood pressure variability (CBPV) vs. Lower real CBPV was evaluated on Interventricular septum thickness (p=<0.00001). Higher real circadian blood pressure variability in hypertensive men was associated with greater interventricular septum thickness (1.381 vs 1.270; P<0.00001) and other morpho-functional changes.