Combined hypertension was significantly associated with greater odds of cardiovascular disease compared to no combined hypertension after multivariable adjustment (OR 1.27; 95% CI 1.03-1.56).
Cross-Sectional (n=17,846)
Is combined systolic and diastolic hypertension associated with increased odds of cardiovascular disease compared to those without combined hypertension?
Combined systolic and diastolic hypertension, but not isolated systolic or diastolic hypertension, is independently associated with increased odds of cardiovascular disease, highlighting the need to manage both parameters.
Odds Ratio: 1.27 (95% CI 1.03–1.56)
Objective: The association between different types of hypertension (HTN) and cardiovascular disease (CVD) is unclear. We aim to examine the association of isolated systolic, diastolic, and combined HTN (iSHTN, iDHTN, cHTN) with CVD. Design and method: A cross-sectional study using the 2017-2023 NHANES included adults with BP >/=1 measurements. The association of iSHTN (SBP >/=130), iDHTN (DBP >/=80), and cHTN (SBP >/=130 and DBP >/=80) with composite of CVD (history of congestive heart failure, coronary heart disease, angina pectoris, heart attack, and stroke) was examined by multiple logistic regression. Results: Of 17,846 participants >/=18 years old, the mean±SD age was 51±19 years, and 53% were female. The most common type of HTN was cHTN (18%) followed by iSTHN (13%) and iDHTN (11%). The prevalence of CVD was 4.86%. Mean SBP was significantly higher in participants with iSHTN than those without iSHTN (142.8±12.2 vs. 116.9±17.7, mean difference 95%CI 25.9 25.1, 26.8 mmHg). Participants with iDHTN had greater mean DBP compared to those without iDHTN (84.3±3.7 vs. 70.6±11.6, mean difference 13.7 13.1, 14.3 mmHg). Compared to participants without cHTN, those with cHTN had significantly higher mean SBP and DBP (SBP: 147.5±15.6 vs. 114.8±14.9, mean difference 32.7 32.1, 33.3; DBP 90.3±8.4 vs. 68.7±9.2, mean difference 21.6 21.2, 21.9 mmHg). Participants with iSHTN and cHTN had 2.66 and 1.25 times significantly higher odds of CVD compared to those without iSHTN and cHTN, respectively (ORiSHTN 95%CI 2.66 2.35, 3.02; ORcHTN 1.25 1.10, 1.42); however, participants with iDHTN had 0.54 times significantly lower odds of CVD compared to those without iDHTN (ORiDHTN 0.54 0.44, 0.66). After adjusting for age, gender, race, ethnicity, level of education, body mass index, mean SBP and DBP, history of diabetes mellitus, hyperlipidemia, and high-sensitivity CRP, only participants with cHTN had significantly greater odds of CVD compared to those without cHTN (ORiSHTN 0.99 0.83, 1.19; ORiDHTN 1.05 0.83, 1.34; ORcHTN 1.27 1.03, 1.56). Conclusions: cHTN is the most common BP type and is only positively associated with CVD. CVD risk prevention, specifically HTN management, should focus on both SBP and DBP.
Tantisattamo et al. (Fri,) conducted a cross-sectional in Cardiovascular disease (n=17,846). Combined hypertension (cHTN) vs. No combined hypertension was evaluated on Composite of CVD (history of congestive heart failure, coronary heart disease, angina pectoris, heart attack, and stroke) (OR 1.27, 95% CI 1.03-1.56). Combined hypertension was significantly associated with greater odds of cardiovascular disease compared to no combined hypertension after multivariable adjustment (OR 1.27; 95% CI 1.03-1.56).
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