A high blood neutrophil/lymphocyte ratio is significantly associated with a higher prevalence of extracranial (OR 1.88) and intracranial (OR 1.87) atherosclerosis in neurologically healthy adults.
Cross-Sectional (n=950)
No
Does a high blood neutrophil/lymphocyte ratio associate with the presence of cerebral large-artery atherosclerosis and cerebral small-vessel disease in neurologically healthy individuals?
A high blood neutrophil/lymphocyte ratio is independently associated with the presence of asymptomatic cerebral large-artery atherosclerosis, but not small-vessel disease, suggesting a differential role of inflammation in these vascular pathologies.
Odds Ratio: 1.88 (95% CI 1.14–3.09)
Absolute Event Rate: 17.7% vs 9.2%
p-value: p=0.01
Background 95% confidence interval: 1.14–3.09; p = 0.01] and IC atherosclerosis odds ratio: 1.87; 95% confidence interval: 1.15–3.06; p = 0.01) were more prevalent in the highest NLR tertile group than in the lowest NLR tertile group after adjustment for cardiovascular risk factors. However, no significant differences were found in the prevalence of CSVD indices (SLI and WMHs) among the three NLR tertile groups. Conclusions: A high NLR is associated with the development of cerebral LAA but not CSVD.
Chung et al. (Wed,) conducted a cross-sectional in Cerebral large-artery atherosclerosis (n=950). High blood neutrophil/lymphocyte ratio (highest tertile) vs. Low blood neutrophil/lymphocyte ratio (lowest tertile) was evaluated on Extracranial (EC) atherosclerosis (OR 1.88, 95% CI 1.14-3.09, p=0.01). A high blood neutrophil/lymphocyte ratio is significantly associated with a higher prevalence of extracranial (OR 1.88) and intracranial (OR 1.87) atherosclerosis in neurologically healthy adults.
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