OBJECTIVE: -induced acute lung injury and resolution remain unclear. METHODS: -induced acute lung injury in mice, we exposed eight-week-old female mice to filtered air or 1.5 ppm O3 for 4h and assessed lung injury markers at 12h, 36h, 60h, 108h, and 204h post-exposure. RESULTS: exposure also induced time-dependent alterations in multiple cytokines, including eotaxin, G-CSF, KC, MIP-1α, MIP-1β, IL-5, IL-6, IL-12, and MCP-1. At 12h post-exposure, severe denudation of airway epithelial cells was observed. Basal cell proliferation peaked between 36h and 60h, while ciliated cell restoration began at 60h, with normal epithelial composition achieved by 204h. CONCLUSION: -induced acute lung injury and repair mechanisms.
Paudel et al. (Mon,) studied this question.