Overt (Stage C) heart failure was associated with a significantly lower stroke volume index (31.9 vs. 36.8 mL/m2, p<0.001) and higher heart rate compared to Stage A/B controls.
Case-Control (n=161)
Do hemodynamic variables from 24-hour pulse wave analysis differ between patients with Stage A/B and Stage C heart failure?
Low 24-hour ambulatory stroke volume index combined with high heart rate is predictive of overt Stage C heart failure and may aid in HF staging.
Absolute Event Rate: 31.9% vs 36.8%
p-value: p=<.001
Objective: We investigated the hemodynamic evolution of heart failure (HF) from hypertension, with emphasis on indicators of systemic perfusion. Design and method: In a case-controlled paradigm, after matching for mean arterial pressure (MAP), we compared hemodynamic variables from 24-hour pulse wave analysis (Mobil-O-Graph, ARCSolver software) in at-risk controls (Stage A/B HF) and patients with history of overt (Stage C) HF. HF patients were subsequently stratified by ejection fraction (EF): low (40%). Results: Hemodynamic differences (mean +SEM) between Stage A/B (n=109) and Stage C HF (n=52) were, respectively: SVI (36.8 vs. 31.9 mL/m2, p75 bpm increased specificity to 84%. Conclusions: SVI at any given HR is predictably lower and HR is higher in Stage C HF compared to Stage A/B controls, irrespective of EF. Low 24-hour ambulatory SVI, especially when combined with high 24-hr HR, is predictive of overt HF and could help improve HF staging.
Izzo et al. (Fri,) conducted a case-control in Heart failure from hypertension (n=161). Overt (Stage C) heart failure vs. Stage A/B heart failure (at-risk controls) was evaluated on Stroke volume index (SVI) (p=<.001). Overt (Stage C) heart failure was associated with a significantly lower stroke volume index (31.9 vs. 36.8 mL/m2, p<0.001) and higher heart rate compared to Stage A/B controls.