Adipocyte angiotensinogen deficiency prevented high fat-induced elevations in systolic blood pressure in male mice (126 ± 2 mm Hg vs 134 ± 2 mm Hg in controls).
Does adipocyte angiotensinogen deficiency prevent obesity-induced hypertension in male mice?
Adipocyte angiotensinogen deficiency prevents high fat-induced elevations in plasma angiotensin II and systolic blood pressure in mice, indicating adipose tissue is a major source of angiotensin II in obesity hypertension.
Absolute Event Rate: 126% vs 134%
Previous studies demonstrated that diet-induced obesity increased plasma angiotensin II concentrations and elevated systolic blood pressures in male mice. Adipocytes express angiotensinogen and secrete angiotensin peptides. We hypothesize that adipocyte-derived angiotensin II mediates obesity-induced increases in systolic blood pressure in male high fat-fed C57BL/6 mice. Systolic blood pressure was measured by radiotelemetry during week 16 of low-fat or high-fat feeding in Agt(fl/fl) and adipocyte angiotensinogen-deficient mice (Agt(aP2)). Adipocyte angiotensinogen deficiency had no effect on diet-induced obesity. Basal 24-hour systolic blood pressure was not different in low fat-fed Agt(fl/fl) compared with Agt(aP2) mice (124 ± 3 versus 128 ± 3 mm Hg, respectively). In Agt(fl/fl) mice, high-fat feeding significantly increased systolic blood pressure (24 hours; 134 ± 2 mm Hg; P<0.05). In contrast, high fat-fed Agt(aP2) mice did not exhibit an increase in systolic blood pressure (126 ± 2 mm Hg). Plasma angiotensin II concentrations were increased by high-fat feeding in Agt(fl/fl) mice (low fat, 32 ± 14; high fat, 219 ± 58 pg/mL; P<0.05). In contrast, high fat-fed Agt(aP2) mice did not exhibit elevated plasma angiotensin II concentrations (high fat, 18 ± 7 pg/mL). Similarly, adipose tissue concentrations of angiotensin II were significantly decreased in low fat- and high fat-fed Agt(aP2) mice compared with controls. In conclusion, adipocyte angiotensinogen deficiency prevented high fat-induced elevations in plasma angiotensin II concentrations and systolic blood pressure. These results suggest that adipose tissue serves as a major source of angiotensin II in the development of obesity hypertension.
Yiannikouris et al. (Tue,) conducted a other in Obesity-induced hypertension. Adipocyte angiotensinogen deficiency (Agt(aP2)) vs. Agt(fl/fl) controls was evaluated on Systolic blood pressure. Adipocyte angiotensinogen deficiency prevented high fat-induced elevations in systolic blood pressure in male mice (126 ± 2 mm Hg vs 134 ± 2 mm Hg in controls).