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Reversible formation of carbon–carbon bonds under physiological conditions by enzyme catalysis allows the generation and in situ screening of a dynamic mixture of biologically significant compounds. Generation of the dynamic library by incubation of the three sugars 1 a–c with two equivalents of sodium pyruvate in the presence of N-acetylneuraminic acid aldolase and wheat germ agglutinin resulted in amplification of sialic acid 1 a (see scheme).
Lins et al. (Mon,) studied this question.