Serum high-sensitivity C-reactive protein levels and carotid intima-media thickness were not significantly correlated with the severity of depression one month after a myocardial infarction.
Cross-Sectional (n=154)
No
In patients 1-month post-MI, the presence and severity of depression were not significantly correlated with systemic inflammation (hs-CRP) or the extent of atherosclerosis (CIMT).
Effect estimate: r = 0.079
p-value: p=0.332
Background: The natural history of acute myocardial infarction (AMI) as the most prevalent public health issue in Iran has changed with the introduction of novel therapeutic strategies that have reduced its mortality significantly. Major depressive disorder (MDD) is a prevalent and disabling psychiatric disorder and frequently co-exist with AMI. There are proposed pathophysiological links between the two diseases among which inflammation is the most important. With more patients surviving a myocardial infarction (MI) event, post-MI depression has become an important determinant of disability and mortality. Materials and Methods: In this study we defined a 1-month post-MI depressive scale of 200 patients using Beck's inventory questionnaire II and measured serum high Sensitivity C-Reactive Protein (hs-CRP) and carotid intima-media thickness (CIMT) to look for the association between inflammatory state and atherosclerosis in different depression score categories. Results: Minimum and maximum Beck scores were 1 and 43, respectively with a mean of 13±8. The mean CIMT was 0.77±0.26 mm. Serum hs-CRP level was measured with a mean of 1.51±1.6 mg/L. According to BDI-II scores, 44.2% of patients 1-month post-MI suffered from more than mild depression. Being affected was not correlated with either the level of hs-CRP or CIMT. Nearly 44 percent of patients suffered more than mild depression. There was a negative association between serum hs-CRP level and CIMT as a measure of atherosclerosis in groups of depressed versus non-depressed patients. This may indicate that the extent of atherosclerosis is not correlated with the inflammatory state after MI in depressed versus non-depressed patients. Conclusion: The results of this study indicate that the extent of atherosclerosis is not correlated with the inflammatory state after MI in depressed versus non-depressed patients. Nonetheless, the prognostic indications of increased hs-CRP and depression after AMI remains to be investigated further.
Alizadeh et al. (Fri,) conducted a cross-sectional in Post-Myocardial Infarction Depression (n=154). High-sensitivity C-reactive protein (hs-CRP) and carotid intima-media thickness (CIMT) was evaluated on Correlation between depression score (BDI-II) and serum hs-CRP levels (r = 0.079, p=0.332). Serum high-sensitivity C-reactive protein levels and carotid intima-media thickness were not significantly correlated with the severity of depression one month after a myocardial infarction.