January 1, 1976
View Full PaperProblems in the Assessment of Blood Pressure: The Framingham Study
Structured PICO
Does an averaged series of blood pressure measurements improve the prediction of future cardiovascular disease compared to a single casual measurement in a general cohort?
P
Population
5,209 men and women from the Framingham cohort
I
Intervention
Averaged series of blood pressure measurements
C
Comparator
Single casual blood pressure measurement
O
Outcome
Future cardiovascular disease (cardiovascular sequelae of hypertension)hard clinical
A single casual blood pressure measurement is highly predictive of future cardiovascular risk, validating its use in clinical practice despite the slight predictive advantage of averaged measurements.
Abstract
Gordon, T. (National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland 20014, USA), Sorlie, P. and Kannel, W.B. Problems in the assessment of blood pressure: the Framingham Study. International Journal of Epidemiology 1976, 5: 327–334. The reliability of casual blood pressures for reflecting blood pressure status and predicting cardiovascular sequelae of hypertension was examined in the Framingham cohort of 5209 men and women followed for 18 years. Blood pressures were more variable in persons with higher levels. After controlling for pressure level the degree of variability in an individual at one point in time did not correlate with the degree of variability at another time. Although a single casual measurement does not afford a precise characterization for an individual it was found to be highly predictive of future cardiovascular disease. A series of blood pressure measurements (averaged) improved the predictability somewhat but this seemed to be fully explicable by the greater stability of an average of several measurements as against a single measurement.