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Medical education research contributes to translational science (TS) when its outcomes not only impact educational settings, but also downstream results, including better patient-care practices and improved patient outcomes. Simulation-based medical education (SBME) has demonstrated its role in achieving such distal results. Effective TS also encompasses implementation science, the science of health-care delivery. Educational, clinical, quality, and safety goals can only be achieved by thematic, sustained, and cumulative research programs, not isolated studies. Components of an SBME TS research program include motivated learners, curriculum grounded in evidence-based learning theory, educational resources, evaluation of downstream results, a productive research team, rigorous research methods, research resources, and health-care system acceptance and implementation. National research priorities are served from translational educational research. National funding priorities should endorse the contribution and value of translational education research. Medical education research contributes to translational science (TS) when its outcomes not only impact educational settings, but also downstream results, including better patient-care practices and improved patient outcomes. Simulation-based medical education (SBME) has demonstrated its role in achieving such distal results. Effective TS also encompasses implementation science, the science of health-care delivery. Educational, clinical, quality, and safety goals can only be achieved by thematic, sustained, and cumulative research programs, not isolated studies. Components of an SBME TS research program include motivated learners, curriculum grounded in evidence-based learning theory, educational resources, evaluation of downstream results, a productive research team, rigorous research methods, research resources, and health-care system acceptance and implementation. National research priorities are served from translational educational research. National funding priorities should endorse the contribution and value of translational education research. Agency for Healthcare Research and Quality complex service intervention implementation science medical ICU National Institutes of Health simulation-based medical education translational science Translational science (TS) has been defined historically within the biomedical disciplines. The traditional TS definition involves research that progresses from bench to bedside in three phases. T1 science involves basic laboratory discoveries in the biomedical sciences. T2 science aims to produce evidence of T1 effectiveness at the individual patient level, compare the success of different treatments to identify “the right treatment for the right patient in the right way at the right time,” and translate these results into practice guidelines for patients, clinicians, and policy makers.1Dougherty D Conway PH The “3T's” road map to transform US health care: the “how” of high-quality care.JAMA. 2008; 299: 2319-2321Crossref PubMed Scopus (279) Google Scholar T3 science addresses health-care delivery, community engagement, and preventive services that produce measureable improvements in the health of individuals and society.1Dougherty D Conway PH The “3T's” road map to transform US health care: the “how” of high-quality care.JAMA. 2008; 299: 2319-2321Crossref PubMed Scopus (279) Google ScholarThe biomedical TS imperative has been expressed for at least a century. 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McGaghie et al. (Thu,) studied this question.