New-onset paroxysmal atrial fibrillation was an independent predictor of poor functional outcome in patients hospitalized with intracerebral hemorrhage (OR 10.35; 95% CI 1.08-98.80; P=0.042).
Cohort (n=650)
Does new-onset paroxysmal atrial fibrillation predict poor functional outcome in patients hospitalized with intracerebral hemorrhage?
In patients hospitalized with intracerebral hemorrhage, the development of new-onset paroxysmal atrial fibrillation is a significant independent predictor of poor functional outcomes.
Odds Ratio: 10.35 (95% CI 1.08–98.8)
p-value: p=0.042
Objective: We aimed to assess the prevalence and risk factors of new-onset paroxysmal atrial fibrillation (PAF) in patients hospitalized with ICH and determine whether the new-onset PAF had influenced functional outcomes. Methods: We analyzed a database of all consecutive patients with ICH from October 2013 to May 2022. Univariate and multivariable regression analyses were performed to identify risk factors for new-onset PAF in patients with ICH. Multivariate models were also constructed to assess whether the new-onset PAF was an independent predictor of poor functional outcome, as measured using the modified Rankin scale. Results: This study included 650 patients with ICH, among whom 24 patients had new-onset PAF. In the multivariable model, older age (OR per 10-y increase, 2.26 95% CI, 1.52– 3.35; P < 0.001), hematoma volume (OR per 10-mL increase, 1.80 95% CI, 1.26– 2.57; P =0.001), and heart failure (OR, 21.77 95% CI, 5.52– 85.91; P < 0.001) were independent risk factors for new-onset PAF. In a sensitivity analysis restricted to 428 patients with N-terminal pro-B-type natriuretic peptide (NT-proBNP), older age, larger hematoma volume, heart failure, and increased NT-proBNP were associated with new-onset PAF. After adjusting for baseline variables, new-onset PAF was an independent predictor of poor functional outcome (OR, 10.35 95% CI, 1.08– 98.80; P =0.042). Conclusion: Older age, larger hematoma volume, and heart failure were independent risk factors for new-onset PAF after ICH. Increased NT-proBNP is correlated with higher risks for new-onset PAF when their information is available at admission. Furthermore, new-onset PAF is a significant predictor of poor functional outcome. Keywords: intracerebral hemorrhage, paroxysmal atrial fibrillation, prognostic implication, risk factors
Huang et al. (Mon,) conducted a cohort in Intracerebral Hemorrhage (n=650). New-onset paroxysmal atrial fibrillation vs. No new-onset paroxysmal atrial fibrillation was evaluated on Poor functional outcome, as measured using the modified Rankin scale (OR 10.35, 95% CI 1.08-98.80, p=0.042). New-onset paroxysmal atrial fibrillation was an independent predictor of poor functional outcome in patients hospitalized with intracerebral hemorrhage (OR 10.35; 95% CI 1.08-98.80; P=0.042).