Among urban south Indian type 2 diabetic subjects, higher intima-media thickness was independently associated with peripheral vascular disease (OR 3.9; 95% CI 1.7-9.3; p=0.002 for third vs first tertile).
Cross-Sectional (n=1,755)
In urban south Indian patients with type 2 diabetes, the prevalence of PVD is 8.3%, and carotid IMT is strongly and independently associated with the presence of PVD.
Odds Ratio: 3.9 (95% CI 1.7–9.3)
p-value: p=0.002
We investigated the prevalence of peripheral vascular disease (PVD) and its association with preclinical atherosclerotic markers intima-media thickness (IMT) and arterial stiffness among 1755 urban south Indian type 2 diabetic subjects recruited from the Chennai Urban Rural Epidemiology Study (CURES). Doppler studies were performed, and PVD was defined as ankle-brachial index (ABI) of ≤0.9. IMT of the common carotid artery was determined using high-resolution B-mode ultrasonography, and augmentation index (AGI) was measured using the Sphygmocor apparatus. The overall prevalence of PVD was 8.3% (age-standardized 6.5%). The prevalence of PVD was higher among known diabetic subjects (n = 1401) compared to newly detected diabetic subjects (n = 354) (8.6% vs 6.8%, p = 0.250). The mean IMT and AGI in subjects with PVD were significantly higher compared to subjects without PVD (IMT: 0.99 ± 0.26 mm vs 0.83 ± 0.19 mm; AGI: 28.1 ± 9.6% vs 25.7 ± 9.8%, respectively). IMT was independently associated with PVD even after adjusting for age odds ratio (OR) = 2.9 (1.2-6.7), p = 0.016 for second tertile and OR = 3.9 (1.7-9.3), p = 0.002 for third tertile compared to first tertile. AGI was also associated with PVD in the unadjusted model OR = 1.8 (1.1-3.1), p = 0.027 for second tertile compared to first tertile. However, when adjusted for age, the significance was lost. In conclusion, among urban south Indian type 2 diabetic subjects, the prevalence of PVD is 8.3% and IMT is more strongly associated with PVD than AGI.
Pradeepa et al. (Thu,) conducted a cross-sectional in Type 2 diabetes (n=1,755). Intima-media thickness (IMT) vs. First tertile of IMT was evaluated on Peripheral vascular disease (PVD) (OR 3.9, 95% CI 1.7-9.3, p=0.002). Among urban south Indian type 2 diabetic subjects, higher intima-media thickness was independently associated with peripheral vascular disease (OR 3.9; 95% CI 1.7-9.3; p=0.002 for third vs first tertile).