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Modern cell biology is on the verge of answering Weiss's question. Recent studies have identified the adhesion systems that participate in 'bobbins' (i.e., hemidesmosomes) and the changes in adhesion receptors that can account for keratinocyte activation, that is, the transition of keratinocytes from a sedentary to migratory lifestyle. In this commentary, I will review some of the recent research on changes that occur during activation of normal keratinocytes to wound keratinocytes and discuss the role of integrin receptor modulation in these changes.
Frederick Grinnell (Wed,) studied this question.
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