Anti-nephrin, anti-podocin, and anti-Kirrel1 autoantibodies in post-transplant recurrent focal segmental glomerulosclerosis

The discovery of anti-nephrin autoantibodies as a possible circulating factor in diffuse podocytopathies has led to a paradigm shift in our understanding of the pathogenic mechanisms in diffuse podocytopathies.1 Anti-nephrin autoantibodies have been implicated in both native kidney diffuse podocytopathies and post-transplant recurrent focal segmental glomerulosclerosis (rFSGS), and this emerging framework is reshaping the traditional classification of nephrotic syndrome and has important implications for diagnosis.