What question did this study set out to answer?

This research aims to uncover the adsorption behavior and structural interactions of cell-penetrating peptides at lipid membrane interfaces.

June 4, 2026Chemical Science0 citationsOpen Access

Distinct Adsorption Behavior and Structures of Cell-Penetrating Peptides at a Model Lipid Membrane Interface: A Heterodyne-Detected Vibrational Sum Frequency Generation Spectroscopy Study

SRSubhadip Roy MAMohammed Ahmed AAAniruddha Adhikari

Key Points

This research aims to uncover the adsorption behavior and structural interactions of cell-penetrating peptides at lipid membrane interfaces.
Utilized heterodyne-detected vibrational sum frequency generation spectroscopy to analyze peptide interaction.
Examined distinct structures of arginine-rich cell-penetrating peptides at model lipid membranes.
Identified unique adsorption behaviors of cell-penetrating peptides at the lipid membrane interface.
Revealed specific structural changes in peptides upon interaction with the lipid environment.

Abstract

Arginine-rich cell-penetrating peptides (CPPs) are widely used as molecular delivery vectors, yet the molecular mechanism of their membrane activity and how they penetrate a cell remains unclear. Here, we investigate...

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