What is the clinical evidence from this study?

Study design: Case-Control. Population: Type II Diabetes Mellitus (n=100). Intervention: Type II Diabetes Mellitus vs. Healthy individuals. Primary outcome: Pulmonary function tests (FEV1/FVC ratio, FEF50%, FEF75%) (p=<0.0001).

January 1, 2013Open Access

Pulmonary function tests in type II diabetics in correlation with fasting blood glucose

Q: What are the key findings of this study?

Type II diabetes was associated with a significant reduction in FEV1/FVC ratio, FEF50%, and FEF75% compared to healthy controls (p<0.0001).

Key Result

Type II diabetes was associated with a significant reduction in FEV1/FVC ratio, FEF50%, and FEF75% compared to healthy controls (p<0.0001).

Study Design

Type

Case-Control (n=100)

Multicenter

PICO

Population

100 subjects aged 30-55 years, comprising 50 with type II diabetes and 50 healthy controls, evaluated for pulmonary function.

Exposure / Comparator

Type II Diabetes Mellitus vs Healthy individuals

Primary Outcome

Pulmonary function tests (FEV1/FVC ratio, FEF50%, FEF75%), p=<0.0001

Main Result

p-value: p=<0.0001

Abstract

Background & Objectives: Diabetes mellitus (DM) is a significant public health problem worldwide which is associated with hormonal, metabolic and micro vascular abnormalities. The angiopathic complications affect eyes, kidneys, nervous, cardiovascular and respiratory system, which are primarily due to biochemical alterations in connective tissue. Materials & Methods: In this study, we included 100 subjects, 50 Diabetic (25 Male and 25 Female) and 50 (25 Male and 25 Female) healthy individuals aged 30-55 years. The pulmonary function tests were performed by the computerized spirometer in the Clinical Physiology Lab, Department of Physiology, Dr. PSIMS & RF, Chinnavutapalli. Results: The results of our study showed a statistically significant reduction in FEF50%, FEF75% & FEV1 /FVC ratio in diabetic male subjects when compared with control male subjects (p< 0.0001) and diabetic female subjects showed a reduction in FEV1/FVC which is not statistically significant (p = 0.0004) but we observed a statistically significant reduction in FEF50% & FEF75% in diabetic female subjects when compared with control female subjects (p< 0.0001). On spirometry, Diabetic subjects showed a significant reduction in FEV1/ FVC ratio, FEF 50%, FEF 75% relative to non diabetic controls. Conclusion: We conclude from our study that diabetic subjects showed impairment in lung function. We found a decrease in FEV1/FVC ratio, FEF50% and FEF75% in diabetic subjects as compared to control subjects.