What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Cardiovascular diseases (n=7362). Intervention: Visceral adiposity index (VAI) and atherogenic index of plasma (AIP) vs. First tertile of VAI and AIP. Primary outcome: Risk of cardiovascular diseases (CVDs) (OR 1.48, 95% CI 1.12-1.97, p=0.006).

August 1, 2021Open Access

Visceral adiposity index and atherogenic index of plasma as useful predictors of risk of cardiovascular diseases: evidence from a cohort study in Iran

Key Result

Being in the highest tertile of visceral adiposity index significantly increased the risk of cardiovascular diseases (OR 1.48) compared to the lowest tertile.

Study Design

Type

Cross-Sectional (n=7,362)

Multicenter

Structured PICO

Do high Atherogenic Index of Plasma (AIP) and Visceral Adiposity Index (VAI) predict the risk of cardiovascular diseases in adults?

Population

7,362 adults aged 35 to 65 years of Kurdish ethnicity in Iran were evaluated cross-sectionally to assess the association of visceral adiposity index and atherogenic index of plasma with cardiovascular diseases.

Exposure

High Atherogenic Index of Plasma (AIP) and Visceral Adiposity Index (VAI) (evaluated as the third tertile)

Comparator

Low Atherogenic Index of Plasma (AIP) and Visceral Adiposity Index (VAI) (evaluated as the first tertile)

Outcome

Presence of cardiovascular diseases (CVDs), defined as a history of ischemic heart disease, heart failure, angina, stroke, myocardial infarction, or current use of CVD medicationcomposite

The atherogenic index of plasma and visceral adiposity index are independently associated with an increased risk of cardiovascular diseases and may serve as useful screening tools in the general population.

Main Result

Odds Ratio: 1.48 (95% CI 1.12–1.97)

p-value: p=0.006

Limitations

Cross-sectional nature limits causal inference of the observed associations
Findings cannot be generalized to all age groups and other ethnicities as the study was performed only on adults of Kurdish ethnicity in western Iran

Abstract

BACKGROUND: Visceral adiposity index (VAI) and atherogenic index of plasma (AIP) are relatively new indicators for predicting non-communicable diseases (NCDs). Therefore, the present study was done to assess the association of AIP and VAI with risk of cardiovascular diseases (CVDs). METHODS: This cross-sectional study was conducted on 7,362 individuals aged between 35 and 65 years old participated in Ravansar non-communicable diseases (RaNCD) cohort study. AIP was calculated based on levels of triglyceride and high -density lipoprotein cholesterol (HDL-C). VAI was calculated using values of body mass index (BMI), waist circumference (WC), triglyceride, and HDL-C. Logistic regression models were used to assess the association of AIP and VAI with risk of CVDs. RESULTS: Mean values of anthropometric indices, lipid profile, AIP, and VAI were significantly higher in patients with CVDs than individuals without CVDs (P < 0.001). Mean values of anthropometric indices, lipid profile, and NCDs including hypertension, dyslipidemia, diabetes, metabolic syndrome (MetS), and CVDs in the third tertile of AIP and VAI were significantly increased compared to the first tertile (P < 0.001). After adjusting confounding factors, risk of CVDs in the third tertile of AIP was (OR = 1.32, 95 % CI: 1.03, 1.69) significantly increased compared to the first tertile. Risk of CVDs in the third tertile of VAI was (OR = 1.48, 95 % CI: 1.12, 1.97) significantly increased compared to the first tertile. CONCLUSIONS: According to the findings, AIP and VAI were positively associated with risk of CVDs. Therefore, AIP and VAI can be useful in identifying high-risk subgroups of CVDs in general population.

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