Spinal cord injury was associated with significantly higher aortic pulse wave velocity compared to matched able-bodied controls (1,274 vs 948 cm/s; P<0.05).
Case-Control (n=21)
Does spinal cord injury increase aortic pulse wave velocity in men without metabolic syndrome compared to able-bodied controls?
Aortic pulse wave velocity is significantly higher in men with spinal cord injury compared to matched controls, suggesting increased arterial stiffness and CAD risk even in the absence of metabolic syndrome.
Absolute Event Rate: 1274% vs 948%
p-value: p=<0.05
BACKGROUND/OBJECTIVE: The most significant complication and leading cause of death for people with spinal cord injury (SCI) is coronary artery disease (CAD). It has been confirmed that aortic pulse wave velocity (PWV) is an emerging CAD predictor among able-bodied individuals. No prior study has described PWV values among people with SCI. The objective of this study was to compare aortic (the common carotid to femoral artery) PWV, arm (the brachial to radial artery) PWV, and leg (the femoral to posterior tibial artery) PWV in people with SCI (SCI group) to able-bodied controls (non-SCI group). METHODS: Participants included 12 men with SCI and 9 non-SCI controls matched for age, sex, height, and weight. Participants with a history of CAD or current metabolic syndrome were excluded. Aortic, arm, and leg PWV was measured using the echo Doppler method. RESULTS: Aortic PWV (mean +/- SD) in the SCI group (1,274 +/- 369 cm/s) was significantly higher (P < 0.05) than in the non-SCI group (948 +/- 110 cm/s). There were no significant between-group differences in mean arm PWV (SCI: 1,152 +/- 193 cm/s, non-SCI: 1,237 +/- 193 cm/s) or mean leg PWV (SCI: 1,096 +/- 173 cm/s, non-SCI: 994 +/- 178 cm/s) values. CONCLUSIONS: Aortic PWV was higher among the SCI group compared with the non-SCI group. The higher mean aortic PWV values among the SCI group compared with the non-SCI group indicated a higher risk of CAD among people with SCI in the absence of metabolic syndrome.
Miyatani et al. (Thu,) conducted a case-control in Spinal cord injury (n=21). Spinal cord injury vs. Able-bodied controls was evaluated on Aortic pulse wave velocity (PWV) (p=<0.05). Spinal cord injury was associated with significantly higher aortic pulse wave velocity compared to matched able-bodied controls (1,274 vs 948 cm/s; P<0.05).