Self-reported anxiety or depression in patients with rheumatoid arthritis was associated with significantly greater treatment dissatisfaction (OR 2.28), work impairment, and disability.
Cross-Sectional (n=1,015)
Yes
Does concomitant anxiety or depression worsen treatment satisfaction and economic outcomes in patients with rheumatoid arthritis?
Concomitant anxiety or depression in rheumatoid arthritis patients is associated with significantly worse treatment satisfaction, greater disability, and increased work impairment.
Odds Ratio: 2.28 (95% CI 1.54–3.37)
Absolute Event Rate: 38.2% vs 16.6%
p-value: p=<0.001
Abstract Background The prevalence of mood disturbances such as anxiety and depression is greater in rheumatoid arthritis (RA) patients than in the general population. Given this association, the primary aim of this study was to assess the incremental impact of anxiety or depression on patients with RA from the United States of America (USA) and Europe, independent of the impact of the underlying RA disease. Methods Rheumatologists ( n = 408) from the USA and 5 European countries completed patient record forms for a predetermined number of RA patients who consulted consecutively during the study period; these patients completed patient-reported questionnaires. Descriptive statistics and multivariate regression were used to investigate the relationship between anxiety and depression with treatment and economic outcomes in RA patients. Results Of 1015 physician and patient pairs who completed all relevant questionnaire sections, 390 (38.4%) patients self-reported anxiety or depression, while 180 (17.7%) patients were reported to have anxiety or depression by their physicians. Controlling for age, gender, body mass index and clinical factors (flaring and severity), multiple regression analyses suggested that patients with anxiety or depression more often experienced treatment dissatisfaction (odds ratio OR 2.28; P < .001), had greater impairment in work (coefficient β = 11.82; P = .001) and usual activity (β = 14.73; P < .001), greater disability (β = .35; P < .001), and more often reported unemployment (OR 1.74; P = .001). Multinomial logistic regression revealed discordance between physician and patient satisfaction with treatment. For patients reporting anxiety or depression, physicians were more often satisfied with achievement of current disease control than patients (relative risk ratio 2.19; P = .002). Conclusion Concomitant anxiety or depression was associated with a significant incremental impact on the health-related quality of life and economic aspects of life of patients with RA. In light of observed differences between physician recognition of patient anxiety and/or depression versus patient reporting of anxiety and/or depression symptoms, further research is warranted to develop optimal screening and management of depression and anxiety in patients with RA.
Peterson et al. (Mon,) conducted a cross-sectional in Rheumatoid arthritis (n=1,015). Anxiety or depression vs. No anxiety or depression was evaluated on Patient-reported treatment dissatisfaction (OR 2.28, 95% CI 1.54-3.37, p=<0.001). Self-reported anxiety or depression in patients with rheumatoid arthritis was associated with significantly greater treatment dissatisfaction (OR 2.28), work impairment, and disability.