Treatment of elderly AMI patients in Minneapolis/St. Paul was associated with higher 7.5-year survival compared to Göteborg (27.8% vs 17.2%), possibly due to greater PCI utilization.
Cohort (n=1,403)
Yes
Does treatment in a US center with higher PCI utilization improve long-term survival in elderly AMI patients compared to a Swedish center?
Higher utilization of PCI in elderly AMI patients in the US was associated with better long-term survival compared to a Swedish cohort with lower PCI use.
Effect estimate: HR 0.66 (men), HR 0.49 (women) (95% CI 0.50-0.88 (men), 0.36-0.67 (women))
Absolute Event Rate: 27.8% vs 17.2%
AIMS: International studies provide an opportunity to compare treatment approaches and outcomes. The present study compares elderly hospitalized acute myocardial infarction (AMI) patients in Minneapolis/St. Paul, USA (MSP) and Göteborg, Sweden (GB). METHODS AND RESULTS: A population-based sample of hospitalized AMI (ICD-9 410) patients aged ≥75 in MSP and GB in 2001-02 was abstracted by trained nurses. Mortality was ascertained from medical records and death certificates. Demographics, cardiovascular procedures, and prescription medications were compared using sex-specific generalized linear models. Adjusted hazard ratios (HR) were calculated with Cox regression. In MSP 839 (387 men, 452 women) and in GB 564 (275 men, 289 women) patients were identified. Age was similar (men: MSP 83 ± 7, GB 82 ± 5; women: MSP 84 ± 6, GB 84 ± 6) yet MSP patients had more previous cardiovascular comorbidities and procedures (PCI/CABG). Guideline-based medication use was high in both locations. MSP patients were significantly more likely to undergo PCI (men: MSP 33%, GB 7%; women: MSP 30%, GB 7%). Survival at 7.5 years was 27.8% among MSP patients (men: 26.6%, women: 28.8%) and 17.2% among GB patients (men: 17.5%, women: 17.0%). After adjustment for baseline characteristics and guideline-based therapies, survival was higher among MSP men HR: 0.66, 95% confidence interval (CI): 0.50-0.88 and women (HR: 0.49, 95% CI: 0.36-0.67) compared with GB. CONCLUSION: In MSP and GB, guideline-based therapy use was high. However, PCI use was markedly higher in MSP. Long-term survival was better among elderly men and women in MSP compared with GB possibly related to greater utilization of PCI.
Smith et al. (Tue,) conducted a cohort in Acute myocardial infarction (n=1,403). Treatment in Minneapolis/St. Paul vs. Treatment in Göteborg was evaluated on Survival at 7.5 years (HR 0.66 (men), HR 0.49 (women), 95% CI 0.50-0.88 (men), 0.36-0.67 (women)). Treatment of elderly AMI patients in Minneapolis/St. Paul was associated with higher 7.5-year survival compared to Göteborg (27.8% vs 17.2%), possibly due to greater PCI utilization.