Higher small artery elasticity was associated with a lower risk of incident cardiovascular disease (HR 0.71 per standard-deviation increase; 95% CI 0.61-0.83; P<0.0001).
Cohort (n=6,235)
Yes
Does small artery elasticity predict incident cardiovascular disease in older adults without symptomatic CVD?
Lower small artery elasticity, but not large artery elasticity, provides independent prognostic information for incident cardiovascular events in asymptomatic older adults.
Hazard Ratio: 0.71 (95% CI 0.61–0.83)
p-value: p=< 0.0001
Functional biomarkers like large artery elasticity (LAE) and small artery elasticity (SAE) may predict cardiovascular disease (CVD) events beyond blood pressure. The authors examined the prognostic value of LAE and SAE for clinical CVD events among 6,235 Multi-Ethnic Study of Atherosclerosis participants who were initially aged 45-84 years and without symptomatic CVD. LAE and SAE were derived from diastolic pulse contour analysis. During a median 5.8 years of follow-up between 2000 and 2008, 454 adjudicated CVD events occurred, including 256 cases of coronary heart disease (CHD), 93 strokes, and 126 heart failures (multiple diagnoses were possible). After adjustment for age, race/ethnicity, sex, clinic, height, heart rate, body mass index, systolic and diastolic blood pressure, use of antihypertensive and cholesterol-lowering medications, smoking, total cholesterol, high density lipoprotein cholesterol, triglycerides, diabetes, and high-sensitivity C-reactive protein, the hazard ratio for any CVD per standard-deviation increase in SAE was 0.71 (95% confidence interval: 0.61, 0.83; P < 0.0001). The lowest (stiffest) SAE quartile had a hazard ratio of 2.28 (95% confidence interval: 1.55, 3.36) versus the highest (most elastic) quartile. The net reclassification index, conditional on base risk, was 0.11. SAE was significantly associated with future CHD, stroke, and heart failure. After adjustment, LAE was not significantly related to CVD. In asymptomatic participants free of overt CVD, lower SAE added prognostic information for CVD, CHD, stroke, and heart failure events.
Duprez et al. (Mon,) conducted a cohort in Without symptomatic cardiovascular disease (n=6,235). Small artery elasticity (SAE) vs. Lower small artery elasticity was evaluated on Incident cardiovascular disease (CVD) events (HR 0.71, 95% CI 0.61-0.83, p=< 0.0001). Higher small artery elasticity was associated with a lower risk of incident cardiovascular disease (HR 0.71 per standard-deviation increase; 95% CI 0.61-0.83; P<0.0001).