Key points are not available for this paper at this time.
. The tumor-suppressive effect of the inhibitor appears to be non-tumor cell-autonomous and is likely mediated by components of the tumor microenvironment, including macrophages that commonly adopt alternatively activated states and support tumor growth. Our findings suggest a potential role for PIP4K activity in tumor-associated macrophages and provide a rationale for further exploring pharmacological targeting of these lipid kinases in cancer.
He et al. (Fri,) studied this question.