In obese adolescents with PCOS, impaired glucose tolerance was associated with lower first phase insulin levels (207.9 vs 357.0 muu/mL; P=0.025) and a decreased glucose disposition index.
Cross-Sectional (n=21)
In obese adolescents with PCOS, impaired glucose tolerance is driven by decreased first-phase insulin secretion and increased hepatic glucose production, and is associated with an absence of nocturnal blood pressure dipping, heralding early cardiovascular risk.
Absolute Event Rate: 207.9% vs 357%
p-value: p=0.025
The roles of insulin resistance and insulin secretion in the pathogenesis of glucose intolerance in polycystic ovary syndrome (PCOS) were evaluated in 11 adolescents with impaired glucose tolerance (IGT) and 10 with normal glucose tolerance (NGT). Hepatic glucose production and insulin-stimulated glucose disposal were measured using 6,6-(2)H(2)glucose and a 3-h hyperinsulinemic (80 mu/m(2).min)-euglycemic clamp. First and second phase insulin secretions were evaluated during a hyperglycemic clamp. Automated blood pressure measurements were made to assess the nocturnal change in blood pressure. Hepatic glucose production was significantly higher in IGT vs. NGT. Insulin-stimulated glucose disposal was not different between the two groups. The first phase insulin level was lower in IGT (207.9 +/- 21.0 vs. 357.0 +/- 62.9 muu/mL; P = 0.025; 1247 +/- 126 vs. 2142 +/- 377 pmol/L) without a difference in second phase insulin. The glucose disposition index (product of insulin sensitivity x first phase insulin) was lower in IGT vs. NGT (278 +/- 40 vs. 567 +/- 119 mg/kg.min; P = 0.023; 1546 +/- 223 vs. 3249 +/- 663 micromol/kg.min). The glucose disposition index correlated inversely with OGTT glucose concentrations at 30, 60, and 120 min. Adolescents with PCOS-IGT lacked the normal nocturnal decline in blood pressure. We conclude that in obese adolescents with PCOS, glucose intolerance is associated with 1) decreased first phase insulin secretion, 2) decreased glucose disposition index, and 3) increased hepatic glucose production. These metabolic abnormalities are precursors of type 2 diabetes and are present early in the course of PCOS. Furthermore, the absence of nocturnal dipping in blood pressure may herald the early expression of cardiovascular disease risk in these adolescents.
Arslanian et al. (Mon,) conducted a cross-sectional in Polycystic Ovary Syndrome (n=21). Impaired glucose tolerance vs. Normal glucose tolerance was evaluated on First phase insulin level (p=0.025). In obese adolescents with PCOS, impaired glucose tolerance was associated with lower first phase insulin levels (207.9 vs 357.0 muu/mL; P=0.025) and a decreased glucose disposition index.