Fiber type classification serves as an organizing principle to simplify the complex interactions between major proteins involved in skeletal muscle force generation and contraction.
This review provides a systems biology perspective on skeletal muscle physiology by using fiber type classification to simplify the complex interactions of proteins involved in force generation.
Abstract Skeletal muscle force generation and contraction are fundamental to countless aspects of human life. The complexity of skeletal muscle physiology is simplified by fiber type classification where differences are observed from neuromuscular transmission to release of intracellular Ca 2+ from the sarcoplasmic reticulum and the resulting recruitment and cycling of cross‐bridges. This review uses fiber type classification as an organizing and simplifying principle to explore the complex interactions between the major proteins involved in muscle force generation and contraction. WIREs Syst Biol Med 2012. doi: 10.1002/wsbm.1184 This article is categorized under: Physiology > Mammalian Physiology in Health and Disease Models of Systems Properties and Processes > Organ, Tissue, and Physiological Models
Greising et al. (Wed,) conducted a review in Skeletal muscle physiology. Fiber type classification serves as an organizing principle to simplify the complex interactions between major proteins involved in skeletal muscle force generation and contraction.