Type 2 diabetes in sedentary overweight adults was associated with reduced early diastolic relaxation (P<0.05), despite non-significant differences in overall diastolic impairment (69% vs 40%, P=0.18).
Cross-Sectional (n=28)
Does type 2 diabetes impair diastolic function in sedentary overweight subjects compared to matched nondiabetic subjects?
Type 2 diabetes is associated with impaired early diastolic relaxation independent of age and body composition in sedentary overweight subjects.
Absolute Event Rate: 69% vs 40%
p-value: p=0.18
Purpose: This study aimed to determine whether sedentary overweight subjects with type 2 diabetes have impaired diastolic function compared with equally sedentary and overweight nondiabetic subjects. Methods: Mitral valve pulsed Doppler echocardiography and tissue Doppler imaging (TDI) were used to assess left ventricular structure and diastolic function in 40- to 60-yr-old sedentary overweight subjects with type 2 diabetes (N = 13) and age- and body mass-matched sedentary nondiabetic subjects (N = 15). Pseudonormal filling was identified using preload reduction and TDI. Results: Traditional Doppler mitral inflow parameters were not different between groups; however, early diastolic relaxation, as measured by peak early mitral annular velocity (E′) and the ratio of E′ and peak late mitral annular velocity (E′/A′), was reduced in type 2 diabetic subjects (P < 0.05). The ratio of peak early mitral inflow (E) to E′ (E/E′), an estimate of left ventricular filling pressure, was also higher in the type 2 diabetes group (P < 0.05). The proportions of diastolic impairment (69 vs 40%) and pseudonormal filling (39 vs 20%) were not different between groups (P = 0.18). Conclusion: These findings suggest that type 2 diabetes has an effect on diastolic function that is independent of age and body composition.
Baldi et al. (Tue,) conducted a cross-sectional in Type 2 diabetes (n=28). Type 2 diabetes vs. Sedentary overweight nondiabetic subjects was evaluated on Diastolic impairment (p=0.18). Type 2 diabetes in sedentary overweight adults was associated with reduced early diastolic relaxation (P<0.05), despite non-significant differences in overall diastolic impairment (69% vs 40%, P=0.18).