Heart failure is characterized by distinct cellular and subcellular adaptations, such as specific myosin heavy chain isoform shifts in atrial tissue and altered light chain expression in dilated cardiomyopathy.
No isoform shift (dominance of the /1 myosin heavy chain) in ventricular myocardium.24 In contrast, isoform shift from a myosin heavy chain to ,B myosin heavy chain in atrial tissue.2' Altered Increased ventricular expression of atrial light chain 1 in DCM26; decreased light chain 2 in DCM.27 Unaltered No change in a skeletal to a cardiac ratio mRNA in DCM and 1CM.2' Altered Increased expression of isoform TnT2.20
Hasenfuß et al. (Mon,) studied this question.
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