Exercise-induced myocardial ischemia was not associated with the release of platelet factor 4.
Observational
Does exercise-stress testing induce release of platelet factor 4 in patients with coronary-artery disease?
The study suggests that platelet factor 4 is not released during exercise-induced myocardial ischemia, challenging previous evidence of platelet activation in this setting.
PLATELETS have long been implicated as a cause of acute myocardial ischemia,1 2 3 but absolute proof is lacking. Attempts to quantitate in vivo platelet activation during myocardial ischemia have led to the development of a number of indexes of platelet involvement, including the measurement of platelet aggregates4 and of platelet-specific proteins such as β-thromboglobulin and platelet factor 4. However, results have been inconsistent5 , 6 and controversial, and platelets may not be involved in acute myocardial ischemia. Recently, Green and his coworkers presented evidence that patients with coronary-artery disease who are undergoing exercise-stress testing have elevations in platelet factor 4,7 a heparin-neutralizing protein . . .
Mathis et al. (Thu,) conducted a observational in Exercise-Induced Myocardial Ischemia. Exercise-induced myocardial ischemia was evaluated on Release of Platelet Factor 4. Exercise-induced myocardial ischemia was not associated with the release of platelet factor 4.