Miconazole-loaded solid lipid nanoparticles: formulation and evaluation of a novel formula with high bioavailability and antifungal activity

BACKGROUND AND OBJECTIVE: Miconazole is a broad-spectrum antifungal drug that has poor aqueous solubility (2.5-fold. CONCLUSION: MN-SLN was more efficient in the treatment of candidiasis with enhanced oral bioavailability and could be a promising carrier for the oral delivery of miconazole.