Pindolol prevented the rise in plasma noradrenaline during psychic stress, whereas noradrenaline rose significantly after placebo (85%), labetalol (95%), metoprolol (63%), and propranolol (55%).
RCT
Double-blind
random
Do different beta-blockers alter plasma catecholamine levels differently during psychic stress in healthy volunteers and hypertensive patients?
Beta-blockers with strong intrinsic sympathomimetic activity, such as pindolol, appear to prevent the rise in plasma catecholamines normally seen during psychic stress.
1 A random double-blind study was performed in healthy volunteers. The immediate effects of three different beta-adrenoceptor blocking agents, metoprolol, pindolol and propranolol, on the plasma concentrations of adrenaline and noradrenaline were compared in a situation of pleasant psychic stimulation during a television-game of tennis. The immediate effects of labetalol in a group of patients with arterial hypertension were studied in a similar experimental situation. 2 During psychic stress the plasma concentration of noradrenaline rose significantly by 85% after placebo, by 95% after labetalol, by 63% after metoprolol and by 55% after propranolol. After pindolol the noradrenaline concentration remained unchanged. 3 During psychic stress the plasma concentration of adrenaline rose significantly by 135% after labetalol, by 110% after metoprolol and by 83% after propranolol. After pindolol and placebo the adrenaline concentration remained unchanged. 4 The present results are taken to indicate that the intrinsic sympathomimetic activity possessed by pindolol prevents the rise in plasma noradrenaline normally seen during psychic stress. It is suggested that beta-adrenoceptor blockers with strong intrinsic sympathomimetic effect reduce the release of catecholamines during psychic stress.
Trap‐Jensen et al. (Thu,) conducted a rct in Healthy volunteers and arterial hypertension. Labetalol, metoprolol, pindolol, and propranolol vs. Placebo was evaluated on Plasma concentrations of adrenaline and noradrenaline during psychic stress. Pindolol prevented the rise in plasma noradrenaline during psychic stress, whereas noradrenaline rose significantly after placebo (85%), labetalol (95%), metoprolol (63%), and propranolol (55%).