Reassessing the hemostatic disorder associated with acute promyelocytic leukemia see comments

of the prothrombin (PT), activated partial thromboplastin (PTT) and thrombin times (TT), increased levels of fibrin degradation products (FDPs), and hypofibrin~genemia.~~~~~~~~ These findings are not diagnostic of any single coagulation disorder, but reflect a complex interaction of several pathophysiologic processes depicted in Fig 1. The first and most generally recognized abnormality is the release of procoagulants from the APL cells resulting in DIC. Several types of procoagulant activity have been found in APL cells capable of activating factor X through both intrinsic and extrinsic pathways, including tissue factorlike