June 1, 1988Open Access

B-raf, a new member of the raf family, is activated by DNA rearrangement.

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Abstract

Complementary DNA clones of a putative transforming gene were isolated from NIH 3T3 cells transformed with human Ewing sarcoma DNA. The gene was termed B-raf because it is related to but distinct from c-raf and A-raf. It appears that substitution in the amino-terminal portion of the normal B-raf protein confers transforming activity to the gene.

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Ikawa et al. (Wed,) studied this question.

synapsesocial.com/papers/6a23889e0f6fe640299edbc1 https://doi.org/https://doi.org/10.1128/mcb.8.6.2651

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