Young women with acute ischemic stroke had a significantly higher risk of poor outcomes (mRS 3-6) at 12 months compared to men (adjusted OR 3.45; 95% CI 1.43-8.32).
Cohort (n=228)
No
Do young women with acute ischemic stroke have worse 12-month outcomes compared to young men?
Young women with acute ischemic stroke in East China have a significantly higher risk of death or dependency at 1 year compared to young men, highlighting the need for targeted prevention and management.
Odds Ratio: 3.45 (95% CI 1.43–8.32)
BACKGROUND: Data concerning sex differences in clinical characteristics and outcomes of young ischemic stroke (IS) patients in Eastern China are scarce. Understanding sex differences in clinical characteristics and long-term outcomes of young IS patients might provide valuable evidence for designing preventative measures and therapeutic interventions. METHODS: The study included 228 acute IS patients aged up to 50 years recruited in the prospective Nanjing First Hospital Stroke Registry over a 5-year period. Univariable and multivariable logistic regression analyses were performed to determine whether there were sex differences in clinical characteristics and outcomes of young IS patients. RESULTS: =0.005) of women was significantly lower than that of men. Logistic regression showed that young women had poorer outcomes defined as having modified Rankin Scale score of 3-6 at 12 months after the adjustment for history of prior stroke, NIHSS score, and complication of pneumonia (adjusted OR: 3.45; 95% CI: 1.43-8.32). CONCLUSION: Our study indicates that there may be significant differences in clinical characteristics between young women and men with acute IS in East China. Young women were more likely to be dead or dependent at 12 months after stroke onset. More attention should be paid to young women's IS prevention and management in East China.
Geng et al. (Sat,) conducted a cohort in acute ischemic stroke (n=228). Female sex vs. Male sex was evaluated on modified Rankin Scale score of 3-6 at 12 months (adjusted OR 3.45, 95% CI 1.43-8.32). Young women with acute ischemic stroke had a significantly higher risk of poor outcomes (mRS 3-6) at 12 months compared to men (adjusted OR 3.45; 95% CI 1.43-8.32).