Randomized trial demonstrates a new method for creating C(sp3)–C(sp3) bonds in unique chemical structures, suggesting enhanced synthetical capabilities.
Key Points
This research aims to develop a stereoretentive method for constructing C(sp3)–C(sp3) bonds using radical pathways.
Utilized a substrate-controlled approach with nickel catalysis for radical-radical cross-coupling.
Generated transient alkyl radicals from enantioenriched sulfonylhydrazides and primary/secondary alkyl halides.
Achieved cross-coupling without chiral ligands or exogenous agents.
Achieved enantiospecificities ranging from 80% to 96%.
Produced synthetic yields of up to 90% across various scaffolds.
Supported by mechanistic studies indicating radical capture at nickel to preserve chirality.